MOTS-c
A mitochondrial-derived peptide encoded in mitochondrial DNA, studied for exercise-mimetic effects on insulin sensitivity and metabolic regulation.
Research status: Active preclinical research area; considered one of the more mechanistically novel longevity peptides.
This page is a research-orientation summary, not a dosing guide. For anything beyond general background, read the primary literature or talk to a qualified clinician — specifics like amount, frequency, or administration aren't something we publish here.
Selected references
- Cell Metabolism · 2015 The Mitochondrial-Derived Peptide MOTS-c Promotes Metabolic Homeostasis and Reduces Obesity and Insulin Resistance
- Nature Communications · 2021 MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis
- Aging Cell · 2015 The mitochondrial-derived peptide MOTS-c: a player in exceptional longevity?
- ClinicalTrials.gov · 2019 Study of CB4211 in Patients With Nonalcoholic Fatty Liver Disease (NAFLD) and Obesity
Curated from published literature for research orientation. Not an exhaustive review, and not a substitute for reading primary sources.
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