5-Amino-1MQ
A small molecule NNMT inhibitor studied for its downstream effects on cellular NAD+ availability and fat-cell metabolism.
Research status: Preclinical/early-stage; mechanism is well described, human outcome data is limited.
This page is a research-orientation summary, not a dosing guide. For anything beyond general background, read the primary literature or talk to a qualified clinician — specifics like amount, frequency, or administration aren't something we publish here.
Selected references
- Journal of Medicinal Chemistry · 2017 Structure-Activity Relationship for Small Molecule Inhibitors of Nicotinamide N-Methyltransferase
- Biochemical Pharmacology · 2018 Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high fat diet-induced obesity in mice
- Biochemical Pharmacology · 2019 Small molecule nicotinamide N-methyltransferase inhibitor activates senescent muscle stem cells and improves regenerative capacity of aged skeletal muscle
- Diabetes, Obesity and Metabolism · 2024 Nicotinamide N-methyltransferase inhibition mitigates obesity-related metabolic dysfunction
Curated from published literature for research orientation. Not an exhaustive review, and not a substitute for reading primary sources.
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